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  Cationic Polymers based Non-viral Gene Carriers

  Cationic Polymers based Non-viral Gene Carriers ab 58.99 € als Taschenbuch: Pharmaceutical Applications of Nano-vectors in Transfection Technology. Aus dem Bereich: Bücher, Wissenschaft, Technik,

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  • Price: 58.99 EUR excl. shipping
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  Polyamine conjugates for non-viral gene therapy

  Polyamine conjugates for non-viral gene therapy ab 67.99 € als Taschenbuch: polyamine conjugates for DNA and siRNA Transfection. Aus dem Bereich: Bücher, English, International, Gebundene Ausgaben,

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  • Price: 67.99 EUR excl. shipping
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  Biopharmaceuticals

  Biopharmaceuticals ab 78.99 € als Taschenbuch: A Study of Apoptosis and Cell Cycle to Augment Transfection Efficiency in Chinese hamster ovary (CHO) Cells. Aus dem Bereich: Bücher, Wissenschaft, Biologie,

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  • Price: 78.99 EUR excl. shipping
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  Genetic Engineering and Molecular Studies of Insulin Secreting Cells

  This book reveals some details of research done at Marshall University, USA, involving functional aspects of pancreatic beta cells in several experimental models: avian, transgenic mice, and beta-cell lines. In this book you will gain some knowledge of genetic engineering approaches to improve beta-cell insulin secretion which could be applied to manage models and cases of diabetes mellitus. This work is presented as three separate chapters. The first chapter aims to gain an understanding of the expression pattern of CaBP28k in the chicken pancreas and to explore its spatial relationships with insulin in beta cells. The second chapter is to identify the influence of CaBP28k-ablation on the dynamics of [Ca2+]i in response to glucose stimulation in murine beta cells of CaBP28k-KO mice pancreatic islets and wildtype islets. The third chapter is an attempt to elucidate the genomic and non-genomic effects of in vitro CaBP28k-ablation in a cultured beta-cell line. It highlights the effects on the gene expression profile and insulin secretory responses from cultured rat insulinoma cell lines using antisense oligonucleotides transfection.

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  • Price: 40.99 EUR excl. shipping
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  Modulation of cell survival by altering mtDNA damage and repair

  Mitochondrial DNA is constantly exposed to, and damaged by oxygen radicals generated by Electron Transport Chain. This damage can lead to a loss of genetic information about key proteins in the ETC. What may follow is a dysfunction in cellular energy production and cell death, unless it is repaired. An efficient DNA repair mechanism in mitochondria keeps the amount of damage at an acceptably low level. The research in this book explores the ways to modulate the efficiency of mtDNA repair and evaluates its contribution to the overall cell survival. Introduction of Exonuclease III from E.coli into human mitochondria, either through stable transfection, or by protein transduction leads to a disruption of an efficient mtDNA repair and renders cells more sensitive to the oxidative stress. Modulation of mtDNA repair in this way can be a potentially useful treatment strategy for pathological conditions were a destruction of abnormal cells is a desired outcome, as in anticancer therapy. This work may be of interest to students or professionals working in the field of mtDNA repair.

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  • Price: 33.99 EUR excl. shipping
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  Guide to Research Techniques in Neuroscience (eBook, ePUB)

  Modern neuroscience research is inherently multidisciplinary, with a wide variety of cutting edge new techniques to explore multiple levels of investigation. This Third Edition of Guide to Research Techniques in Neuroscience provides a comprehensive overview of classical and cutting edge methods including their utility, limitations, and how data are presented in the literature. This book can be used as an introduction to neuroscience techniques for anyone new to the field or as a reference for any neuroscientist while reading papers or attending talks.. Nearly 200 updated full-color illustrations to clearly convey the theory and practice of neuroscience methods. Expands on techniques from previous editions and covers many new techniques including in vivo calcium imaging, fiber photometry, RNA-Seq, brain spheroids, CRISPR-Cas9 genome editing, and more. Clear, straightforward explanations of each technique for anyone new to the field. A broad scope of methods, from noninvasive brain imaging in human subjects, to electrophysiology in animal models, to recombinant DNA technology in test tubes, to transfection of neurons in cell culture. Detailed recommendations on where to find protocols and other resources for specific techniques. "Walk-through¿ boxes that guide readers through experiments step-by-step

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  • Price: 48.95 EUR excl. shipping
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  Minimalistic immunologically defined gene expression T helper cell 1 (MIDGE-Th1®) vectors coding for Interleukin 12 and -18 in combination with the transfection agent SAINT-18 have systemic antitumoral effects on equine melanomas

  Minimalistic immunologically defined gene expression T helper cell 1 (MIDGE-Th1®) vectors coding for Interleukin 12 and -18 in combination with the transfection agent SAINT-18 have systemic antitumoral effects on equine melanomas: ab 21.21 €

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  • Price: 21.21 EUR excl. shipping
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  Analysis and improvement of the in vitro transfection efficiency of plasmid-DNA encoding for equine IL-12 used for melanoma therapy in horses

  Analysis and improvement of the in vitro transfection efficiency of plasmid-DNA encoding for equine IL-12 used for melanoma therapy in horses: ab 18.8 €

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  • Price: 18.80 EUR excl. shipping

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